Cholera in engineered intestinal tissue
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Biocompatible polymers are used to make a realistic working model of the intestine, with accurately scaled villi. We’re using this model to try and simulate the microenvironments in the intestine, because it is a complex 3-D space with many different cell types and bacteria. In this image, Cholera is green and Caco-2 epithelial cells are blue. Cholera completely covers the epithelial cells after just 2 hours of exposure.