Small molecule profiling and quantitation

Profiling of small molecules in complex mixtures can be done using liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis, and small molecule quantitation can be done using selected reaction monitoring (SRM) / multiple reaction monitoring (MRM) approaches, with samples ranging from clinical research to food and environmental analysis.  These high-throughput methods have a wide linear dynamic range of up to five orders of magnitude and also have very high sensitivity that allows detection of ng/ml amounts of compound in many types of complex biological matrices, including plasma, serum, urine, tissue extracts and cell extracts.