Proliferating epithelial cells in engineered intestine
Select Imaging type:
Select Imaging Category:
Biocompatible polymers are used to make a realistic working model of the intestine, with accurately scaled villi. We’re using this model to try and simulate the microenvironments in the intestine, because it is a complex 3-D space with many different cell types and bacteria. In this image, proliferating epithelial cells are stained green and Caco-2 epithelial cells are blue. This image shows that in our model, epithelial cells divide and move up the villi in a directional manner. In the real intestine, this allows for apoptotic cells to be ‘sloughed away’ and replaced by proliferating cells from below.