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Proteomics and Metabolomics Facility

Service prices

Access to workstation with Proteomics software

Access to workstation with Proteomics software
DescriptionInternal price (Cornell and Cornell affiliates)External price
Software use on Facility's workstation - during business hour (8:30am to 5:00pm) $15/hour $24/hour
Software use on Facility's workstation - overnight or weekends $50/hour inquire
Training on software use $100/hour $160/hour

Intact protein analysis

Sample preparation
DescriptionInternal price (Cornell and Cornell affiliates)External price
Bradford Assay (set up) $40 $64
Bradford Assay (per sample) $5 $8
Affinity depletion of serum high abundant proteins (per sample) $120 $192
Buffer exchange by ultrafiltration/dialysis/spin column (per sample) $25 $40
Spin filtration (per sample) $15 $24
Spin cartridge desalt (per sample) $25 $40
Gel-based protein quantitation for shotgun (per set of samples) $200 $320
Other beads-based affinity enrichment (per sample) $60 $96
Gel-free 8100 separation (per sample) $200 $320
HPLC/MS
DescriptionInternal price (Cornell and Cornell affiliates)External price
Infusion ESI-MS for intact protein MW (per sample) $80 $128
Infusion ESI-MS for intact protein MW setup (set up) $100 $160
nanoinfusion ESI-MS for intact protein MW setup (set up) $100 $160
online desalting intact protein MW (set up) $150 $240
online desalting intact protein MW (per sample) $120 $192
Relative quantitation for intact protein (per hour) $100 $160
HPLC/MS data interpretation
DescriptionInternal price (Cornell and Cornell affiliates)External price
Quantitation analysis for label-free LC-MS/MS (per set of quan) $250 $400
LC/MS spectra slides for presentation (per figure) $200 $320
deconvolution and data analysis (per hour) $100 $160

Post-translational modifications (PTM)

Sample preparation
DescriptionInternal price (Cornell and Cornell affiliates)External price
Bradford Assay (set up) $40 $64
Bradford Assay (per sample) $5 $8
Affinity depletion of serum high abundant proteins (per sample) $120 $192
TMT 10-plex reagent (per set of samples) $750 $1,200
TMT 10-plex labeling and sample preparation (per set of samples) $800 $1,280
TMT 11-plex reagent (per set of samples) $880 $1,408
TMT 11-plex labeling and sample preparation (per set of samples) $880 $1,408
TMT 16-plex reagent (per set of samples) $1,500 $2,400
TMT 16-plex labeling and sample preparation (per set of samples) $1,300 $2,080
Gel-based protein quantitation for shotgun (per set of samples) $200 $320
dimethylation duplex labeling (per set of samples) $350 $560
dimethylation triplex labeling (per set of samples) $450 $720
mini SDS-PAGE (precast) (per gel) $85 $136
Gel imaging (per hour) $60 $96
In-gel Digest/Extraction, manual (set up) $100 $160
In-gel Digest/Extraction, manual (per sample) $50 $80
In-solution digestion (set up) $100 $160
In-solution digestion (per sample) $50 $80
Strap supplier for insolution digestion (per sample) $10 $16
SPE Cleanup, manual (per sample) $25 $40
Beads-based IMAC or TiO2 enrichment (per sample) $60 $96
MCX/MAX Cartridge (manual) (per sample) $60 $96
Other beads-based affinity enrichment (per sample) $60 $96
HRP manual fractionation (per sample) $100 $160
HPLC/MS
DescriptionInternal price (Cornell and Cornell affiliates)External price
Ion exchange chromatography with fractions collection (per sample) $250 $400
high pH reverse phase with fractions collection (per sample) $250 $400
HILIC chromtography with fractions collection (per sample) $250 $400
nanoLC-MS/MS: 90-120min gradient in Orbitrap Fusion/Eclipse (per sample) $250 $400
nanoLC-MS/MS: 90-120min gradient in Orbitrap Eclipse RTS (per sample) $300 $480
LC/MS/MS for protein PTMs in two runs (CID/HCD/ETD) (per sample) $400 $640
Hypothesis-driven LC-MS/MS run for PTM discovery in QTrap (per sample) $160 $256
HPLC/MS data interpretation
DescriptionInternal price (Cornell and Cornell affiliates)External price
Peptide quantitation by extracted ion chromatogram (per hour) $100 $160
MS/MS manual data interpretation and inspection (per hour for all relevant spectra) $100 $160
Quantitation analysis for label-free nanoLC-MS/MS (per set of quan) $250 $400
Customized database interrogation (per database) $75 $120
LC/MS spectra slides for presentation (per figure) $200 $320
Additional database search and report (per hour) $100 $160

Protein identification

Sample preparation
DescriptionInternal price (Cornell and Cornell affiliates)External price
Spin filtration (per sample) $15 $24
Spin cartridge desalt $25 $40
mini SDS-PAGE, precast (per gel) $85 $136
Gel imaging (per hour) $60 $96
In-gel Digest/Extraction, manual (set up) $100 $160
In-gel Digest/Extraction, manual (per sample) $50 $80
In-solution digestion (set up) $100 $160
In-solution digestion (per sample) $50 $80
second enzyme digestion (per sample) $25 $40
ZipTip, manual (per sample) $15 $24
SPE Cleanup, manual (per sample) $25 $40
MCX Cartridge, manual, or Strap (per sample) $60 $96
HPLC/MS
DescriptionInternal price (Cornell and Cornell affiliates)External price
nanoLC-MS/MS: 60min gradient in Orbitrap Fusion (per sample) $200 $320
nanoLC-MS/MS: 90-120min gradient in Orbitrap Fusion (per sample) $250 $400
nanoLC-MS/MS: 240min gradient (per sample) $320 $512
HPLC/MS data interpretation
DescriptionInternal price (Cornell and Cornell affiliates)External price
Customized database interrogation (per database) $75 $120
Additional database search (per hour) $60 $96

Protein-protein interaction & protein complex analysis

Sample preparation
DescriptionInternal price (Cornell and Cornell affiliates)External price
Bradford Assay (set up) $40 $64
Bradford Assay (per sample) $5 $8
Buffer exchange by ultrafiltration/dialysis/spin column (per sample) $25 $40
Spin filtration (per sample) $15 $24
Spin cartridge desalt (per sample) $25 $40
cross linking reaction (per sample) $60 $96
In-gel Digest/Extraction, manual (set up) $100 $160
In-gel Digest/Extraction, manual (per sample) $50 $80
In-solution digestion (set up) $100 $160
In-solution digestion (per sample) $50 $80
Strap supplier for insolution digestion (per sample) $10 $16
second enzyme digestion (per sample) $25 $40
ZipTip, manual (per sample) $15 $24
SPE Cleanup, manual (per sample) $25 $40
MCX/MAX Cartridge, manual (per sample) $60 $96
HPLC/MS
DescriptionInternal price (Cornell and Cornell affiliates)External price
nanoLC-MS/MS: 60min gradient in Orbitrap Fusion/Eclipse (per sample) $200 $320
nanoLC-MS/MS: 90-120min gradient in Orbitrap Fusion/Eclipse (per sample) $250 $400
nanoLC-MS/MS: 90-120min gradient in Orbitrap Eclipse RTS (per sample) $300 $480
HPLC/MS data interpretation
DescriptionInternal price (Cornell and Cornell affiliates)External price
MS/MS manual data interpretation (per hour for all relevant spectra) $100 $160
Manual cross linking data analysis (per X-paired peptides) $165 $264
Quantitation analysis for label-free nanoLC-MS/MS (per set of quan) $250 $400
Customized database interrogation (per database) $75 $120
Additional database search and report (per hour) $60 $96
LC/MS spectra slides for presentation (per figure) $200 $320
Additional database search and report (per hour) $100 $160

Proteomics and metabolomics project consultation

Proteomics and metabolomics project consultation
DescriptionInternal price (Cornell and Cornell affiliates)External price
First consultation free free
Subsequent consultations (under 30 minutes) free free
Subsequent consultations (over 30 minutes) $100/h $160/h
Project design $100/h $160/h

Quantitative (comparative) proteomics

Sample preparation
DescriptionInternal price (Cornell and Cornell affiliates)External price
Bradford Assay (set up) $40 $64
Bradford Assay (per sample) $5 $8
Affinity depletion of serum high abundant proteins (per sample) $120 $192
iTRAQ 4-plex reagent (per set of samples) $280 $448
iTRAQ 4-plex labeling and sample preparation (per set of samples) $500 $800
iTRAQ 8-plex reagent (per set of samples) $560 $896
iTRAQ 8-plex labeling and sample preparation (per set of samples) $700 $1,120
TMT 6-plex reagent (per set of samples) $380 $608
TMT 6-plex labeling and sample preparation (per set of samples) $600 $960
TMT10-plex reagent (per set of samples) $750 $1,200
TMT 10-plex labeling and sample preparation (per set of samples) $800 $1,280
TMT 11-plex reagent (per set of samples) $880 $1,408
TMT 11-plex labeling and sample preparation (per set of samples) $880 $1,408
TMT 16-plex reagent (per set of samples) $1,500 $2,400
TMT 16-plex labeling and sample preparation (per set of samples) $1,300 $2,080
Buffer exchange by ultrafiltration/dialysis/spin column (per sample) $25 $40
Spin filtration (per sample) $15 $24
Gel-based protein quantitation for shotgun (per set of samples) $200 $320
dimethylation duplex labeling (per set of samples) $350 $560
dimethylation triplex labeling (per set of samples) $450 $720
mini SDS-PAGE, precast (per gel) $85 $136
Gel imaging (per hour) $60 $96
ImageQuant analysis for 1D gel bands (per gel) $50 $80
In-solution digestion (set up) $100 $160
In-solution digestion (per sample) $50 $80
Strap supplier for insolution digestion (per sample) $10 $16
MCX/MAX Cartridge (manual) (per sample) $60 $96
HRP manual fractionation (per sample) $100 $160
HPLC/MS
DescriptionInternal price (Cornell and Cornell affiliates)External price
high pH reverse phase with fractions collection (per sample) $250.00 $400.00
nanoLC-MS/MS: 90-120min gradient in Orbitrap Fusion/Eclipse (per sample) $250 $400
nanoLC-MS/MS: 90-120min gradient in Orbitrap Eclipse RTS (per sample) $300 $480
MRM-LC-MS/MS for peptide quantitation 30min gradient (per sample) $120 $192
MRM-LC-MS/MS for peptide quantitation->=60min gradient (per sample) $200 $320
HPLC/MS data interpretation
DescriptionInternal price (Cornell and Cornell affiliates)External price
Quantitation analysis for label-free nanoLC-MS/MS (per set of quan) $250 $400
Customized database interrogation (per database) $75 $120
Additional database search and report (per hour) $100 $160
Additional statistical analysis by Perseus software (per set of data) $300 $480

Targeted metabolomics, lipidomics, and peptide profiling

Sample Preparation for metabolomics/lipidomics
DescriptionInternal price (Cornell and Cornell affiliates)External price
Metabolomics (per sample) $5 $8
Lipidomics (per sample) $8 $13
GCMS derivitization (per sample) $20 $32
GCMS no derivitization (per sample) $8 $13
LC / MS Sample Analysis for metabolomics/lipidomics
DescriptionInternal price (Cornell and Cornell affiliates)External price
Targeted metabolomics method development (one-time) $500 $800
Targeted metabolomics RP analysis (per hour) $100 $160
Targeted metabolomics HILIC analysis (per hour) $100 $160
Targeted lipidomics method development (one-time) $500 $800
Targeted lipidomics analysis (per hour) $100 $160
GC / MS Sample Analysis
DescriptionInternal price (Cornell and Cornell affiliates)External price
Targeted metabolomics method development (one-time) $500 $800
Targeted metabolomics analysis (per hour) $100 $160
LC / MS Data Interpretation
DescriptionInternal price (Cornell and Cornell affiliates)External price
Basic targeted metabolomics with TraceFinder, MultiQuant (per hour) $100 $164
Targeted lipidomics with Lipidsearch, Xcalibur (per batch) $350 $574
Special data analysis requirement (per hour) $100 $164
GC / MS Data Interpretation
DescriptionInternal price (Cornell and Cornell affiliates)External price
Basic targeted metabolomics with TraceFinder (per hour) $100 $164
Special data analysis requirement (per batch) $100 $164
Sample Preparation for peptides
DescriptionInternal price (Cornell and Cornell affiliates)External price
Sample prep optimization, non SOP (per hour) $70 $112
SPE cleanup, manual (per sample) $25 $40
SCX cartridge, manual (per sample) $40 $64
PGC cartridge, manual (per sample) $40 $64
MCX cartridge, manual (per sample) $60 $96
LC / MS Sample Analysis for peptides
DescriptionInternal price (Cornell and Cornell affiliates)External price
MRM-LC-MS/MS for peptide quantitation 30min gradient (per sample) $120 $192
MRM-LC-MS/MS for peptide quantitation >=60min gradient (per sample) $200 $320

Targeted peptide and small molecule quantitation

Sample preparation
DescriptionInternal price (Cornell and Cornell affiliates)External price
Sample prep optimization, non SOP (per hour) $70 $112
SPE cleanup, manual (per sample) $25 $40
SCX cartridge, manual (per sample) $40 $64
PGC cartridge, manual (per sample) $40 $64
MCX cartridge, manual (per sample) $60 $96
Liquid-liquid extraction for small molecules (per sample) $5 $8
Liquid-liquid extraction for lipids (per sample) $10 $16
HPLC / MS
DescriptionInternal price (Cornell and Cornell affiliates)External price
MRM-LC-MS/MS for peptide quantitation 30min gradient (per sample) $120 $192
MRM-LC-MS/MS for peptide quantitation >=60min gradient (per sample) $200 $320
Small molecule quantitation setup/method dev. $1,250 $2,000
Small molecule quantitation <50 samples (per sample) $50 $80
Small molecule quantitation >=50 samples (per sample) $40 $64
Small molecule quantitation setup (per batch) $150 $240
Small molecule standard curve for quantitation + 3 QCs (per analyte) $650 $1,040
HPLC / MS Data Interpretation
DescriptionInternal price (Cornell and Cornell affiliates)External price
Peptide quantitation by extracted ion chromatogram (per hour) $100 $160
MS/MS Manual Data Interpretation (per hour for all relevant spectra) $100 $160
LC/MS spectra slides for presentation (per figure) $200 $320
Basic Targeted Metabolomics with TraceFinder or MultiQuant (per hour) $100 $160
Special data analysis requirement (per hour) $100 $160

Untargeted metabolomics and lipidomics

Sample Preparation
DescriptionInternal price (Cornell and Cornell affiliates)External price
Metabolomics (per sample) $5 $8
Lipidomics (per sample) $8 $13
GCMS derivitization (per sample) $12 $19
LC / MS Sample Analysis
DescriptionInternal price (Cornell and Cornell affiliates)External price
Unargeted metabolomics analysis setup $100 $160
Untargeted metabolomics RP analysis (per hour) $100 $160
Untargeted metabolomics HILIC analysis (per hour) $100 $160
Untargeted lipidomics analysis setup $150 $240
Untargeted lipidomics analysis (per hour) $100 $160
Creatinine assay setup $100 $160
Creatinine assay $10/sample $16/sample
GC / MS Sample Analysis
DescriptionInternal price (Cornell and Cornell affiliates)External price
Untargeted metabolomics analysis setup $150 $240
Untargeted metabolomics analysis (per hour) $100 $160
LC / MS Data Interpretation
DescriptionInternal price (Cornell and Cornell affiliates)External price
Basic untargeted metabolomics with Compound Discoverer (one-time) $200 $320
Basic untargeted lipidomics with Lipidsearch (one-time) $300 $480
Advanced Analysis/Special Requirements (per hour) $100 $160
GC / MS Data Interpretation
DescriptionInternal price (Cornell and Cornell affiliates)External price
Basic Non-Targeted Metabolomics with TraceFinder, Compound Discoverer (one-time) $400 $640
Advanced Analysis/Special Requirements (per hour) $100 $160

Instrument prices

2D Electropheris systems

2D Electropheris systems
DescriptionInternal price (Cornell and Cornell affiliates)External price
Ettan DALTsix + EPS 601 - Use $100/day $160/day
Ettan DALTsix + EPS 601 - Training $100/h inquire

Exion LC / X500B Q-TOF

Exion LC / X500B Q-TOF
DescriptionInternal price (Cornell and Cornell affiliates)External price
X500B Q-TOF (<12 hours) $650/day $1040/day
X500B Q-TOF (24 hours) $800/day $1280/day
Technical refresher (after vendor's training) $150/hour $240/hour

Expedeon GELFrEE 8100 system

Expedeon GELFrEE 8100 system
DescriptionInternal price (Cornell and Cornell affiliates)External price
GELFrEE 8100 - Use inquire inquire
GELFrEE 8100 - Training $100/hr inquire

SpectraMax 384 Plus spectrophotometer (Molecular Devices)

SpectraMax 384 Plus spectrophotometer (Molecular Devices)
DescriptionInternal price (Cornell and Cornell affiliates)External price
SpectraMax 384 Plus - Use $35/hour $56/hour
SpectraMax 384 Plus - Training free free

Typhoon 9400 (GE Healthcare)

Typhoon 9400 (GE Healthcare)
DescriptionInternal price (Cornell and Cornell affiliates)External price
Typhoon 9400 $60/hour $96/hour
Typhoon 9400 training $75/hour $120/hour

UltiMate 3000 RSLCnano / 4000 QTrap

UltiMate 3000 RSLCnano / 4000 QTrap
DescriptionInternal price (Cornell and Cornell affiliates)External price
4000 QTRAP (<4 hours) $300/half day $480/half day
4000 QTRAP (<12 hours) $500/day $800/day
4000 QTRAP (24 hours) $600/day $960/day
Technical refresher (after vendor's training) $150/hour $240/hour

UltiMate 3000 RSLCnano / Orbitrap Fusion

UltiMate 3000 RSLCnano / Orbitrap Fusion
DescriptionInternal price (Cornell and Cornell affiliates)External price
Orbitrap Fusion (<12 hours) $1000/day $1600/day
Orbitrap Fusion (>12 hours) $1250/day $2000/day
Technical refresher (after vendor's training) $150/hour $240/hour

UltiMate 3000 split HPLC

UltiMate 3000 split HPLC
DescriptionInternal price (Cornell and Cornell affiliates)External price
UltiMate 3000 split HPLC (<4 hours) $120/half day $192/half day
UltiMate 3000 split HPLC (<12 hours) $180/day $288/day
UltiMate 3000 split HPLC (24 hours) $200/day $320/day
Training at the Facility $150/hour $240/hour