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Cornell University

Epigenetics

We offer three approaches

ChIP-Seq

Chromatin ImmunoPrecipitation sequencing (ChIP-Seq) is a powerful method for identifying genome-wide DNA binding sites for transcription factors and other proteins. Following ChIP protocols, DNA-bound protein is immunoprecipitated using a specific antibody. The bound DNA is then co-precipitated, purified, and sequenced.

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Single-cell ATAC-Seq

Assay for transposase-accessible chromatin sequencing (ATAC-seq) builds on a process called tagmentation: the simultaneous fragmentation and tagging of a genome with sequencing adaptors without the need to use antibodies. ATAC-Seq identifies accessible regions of the genome. Using 10X Genomics technology, you can identify open chromatin regions at the level of a single cell, and compare variation among cells in a cell population.

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Epigenomics assays: ChIP-seq and ATAC-seq - Presentation by Friederike D√ľndar, Weill Cornell Medicine, March 2020